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Bimetallic Oxidative Addition in Nickel-Catalyzed Alkyl–Aryl Kumada Coupling Reactions

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posted on 27.10.2014, 00:00 by Jan Breitenfeld, Matthew D. Wodrich, Xile Hu
The mechanism of alkyl–aryl Kumada coupling catalyzed by the nickel pincer complex Nickamine was studied. Experiments using radical-probe substrates and DFT calculations established a bimetallic oxidative addition mechanism. Kinetic measurements showed that transmetalation rather than oxidative addition was the turnover-determining step. The transmetalation involved a bimetallic pathway.