Azaphilones and p-Terphenyls from the Mangrove Endophytic Fungus Penicillium chermesinum (ZH4-E2) Isolated from the South China Sea
datasetposted on 2011-05-27, 00:00 authored by Hongbo Huang, Xiaojun Feng, Ze’en Xiao, Lan Liu, Hanxiang Li, Lin Ma, Yongjun Lu, Jianhua Ju, Zhigang She, Yongcheng Lin
Eight secondary metabolites, including three new azaphilones (chermesinones A–C, 1–3), three new p-terphenyls (6′-O-desmethylterphenyllin, 4; 3-hydroxy-6′-O-desmethylterphenyllin, 5; 3′′-deoxy-6′-O-desmethylcandidusin B, 7), and two known p-terphenyls (6, 8), were isolated from the culture of the mangrove endophytic fungus Penicillium chermesinum (ZH4-E2). Their structures were established by spectroscopic analysis. The absolute configuration of 1 was determined by X-ray crystallography. Terphenyls 4, 5, and 6 exhibited strong inhibitory effects against α-glucosidase with IC50 values of 0.9, 4.9, and 2.5 μM, respectively. Terphenyls 7 and 8 showed inhibitory activity toward acetylcholinesterase with IC50 values of 7.8 and 5.2 μM.
acetylcholinesteraseTerphenyls 7spectroscopic analysismangrove endophytic fungus Penicillium chermesinumdeoxyAzaphiloneglucosidase7.8crystallographychermesinone2.5 μ MazaphiloneIC 50 valuesZHSouth China SeaEightcultureconfigurationmetaboliteMangrove Endophytic Fungus Penicillium chermesinum5.2 μ Mhydroxy