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Asymmetric Total Synthesis of (2R)‑Hydroxynorneomajucin, a Norsesquiterpene from Illicium jiadifengpi

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posted on 2022-05-02, 13:04 authored by Charles J. Dooley, Scott D. Rychnovsky
We report the first total synthesis of (2R)-hydroxy­norneomajucin, a norsesquiterpene derived from the Illicium genus. This natural product displays neurotrophic properties. Small molecule neurotrophins have potential as therapeutics in neurodegenerative diseases. Key steps of our synthesis include a Tsuji–Trost reaction, a Pauson–Khand cyclization, and a Nagata hydrocyanation. A simple sequence of reductions and a Mukaiyama hydration introduce the A-ring substituents with the correct configurations. The overall synthesis was completed in 17 steps (longest linear sequence, LLS).

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