cs500667g_si_002.cif (20.51 kB)
Asymmetric Synthesis of Tri- and Tetrasubstituted Trifluoromethyl Dihydropyranones from α‑Aroyloxyaldehydes via NHC Redox Catalysis
datasetposted on 2014-08-01, 00:00 authored by Alyn T. Davies, Philip M. Pickett, Alexandra M. Z. Slawin, Andrew D. Smith
The asymmetric synthesis of tri- and tetrasubstituted trifluoromethyl dihydropyranones via an NHC-catalyzed redox process, introducing methyl, benzyl, and aryl substituents to the C(5) position, is presented. Their substrate-controlled derivatization into δ-lactones and cyclic hemiacetals containing stereogenic trifluoromethyl groups is also described.