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Download fileAsymmetric Synthesis of Tri- and Tetrasubstituted Trifluoromethyl Dihydropyranones from α‑Aroyloxyaldehydes via NHC Redox Catalysis
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posted on 2014-08-01, 00:00 authored by Alyn T. Davies, Philip M. Pickett, Alexandra M. Z. Slawin, Andrew D. SmithThe
asymmetric synthesis of tri- and tetrasubstituted trifluoromethyl
dihydropyranones via an NHC-catalyzed redox process, introducing
methyl, benzyl, and aryl substituents to the C(5) position, is presented.
Their substrate-controlled derivatization into δ-lactones and
cyclic hemiacetals containing stereogenic trifluoromethyl
groups is also described.