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Asymmetric Synthesis of Tertiary Benzylic Alcohols

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posted on 21.01.2011, 00:00 by Monika I. Antczak, Feng Cai, Joseph M. Ready
Vinyl, aryl, and alkynyl organometallics add to ketones containing a stereogenic sulfoxide. Tertiary alcohols are generated in diastereomerically and enantiomerically pure form. Reductive lithiation converts the sulfoxide into a variety of useful functional groups.