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Asymmetric Synthesis of Indole Homo-Michael Adducts via Dynamic Kinetic Friedel–Crafts Alkylation with Cyclopropanes

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posted on 17.05.2013, 00:00 authored by Steven M. Wales, Morgan M. Walker, Jeffrey S. Johnson
An enantioconvergent Friedel–Crafts alkylation of indoles with donor–acceptor cyclopropanes is described. The reaction is catalyzed by pybox•MgI2 and proceeds via a type I dynamic kinetic asymmetric transformation (DyKAT).

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