Asymmetric Synthesis of Indole Homo-Michael Adducts via Dynamic Kinetic Friedel–Crafts Alkylation with Cyclopropanes

Name: Asymmetric Synthesis of Indole Homo-Michael Adducts via Dynamic Kinetic Friedel–Crafts Alkylation with Cyclopropanes
Published: 2013-05-17T00:00:00+00:00
License: https://creativecommons.org/licenses/by-nc/4.0/
Keywords: Indole, enantioconvergent, pybox, Alkylation, indole, proceed, donor, type, alkylation, Asymmetric Synthesis, cyclopropane, Friedel, CyclopropanesAn, Adduct, DyKAT, Dynamic, transformation, Kinetic

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posted on 2013-05-17, 00:00 authored by Steven M. Wales, Morgan M. Walker, Jeffrey S. Johnson

An enantioconvergent Friedel–Crafts alkylation of indoles with donor–acceptor cyclopropanes is described. The reaction is catalyzed by pybox•MgI₂ and proceeds via a type I dynamic kinetic asymmetric transformation (DyKAT).

Asymmetric Synthesis of Indole Homo-Michael Adducts via Dynamic Kinetic Friedel–Crafts Alkylation with Cyclopropanes

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