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Asymmetric Synthesis of Enaminophosphines via Palladacycle-Catalyzed Addition of Ph2PH to α,β-Unsaturated Imines

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posted on 17.08.2012, 00:00 by Yinhua Huang, Renta Jonathan Chew, Sumod A. Pullarkat, Yongxin Li, Pak-Hing Leung
A highly reactive, chemo- and enantioselective addition of diphenylphosphine to α,β-unsaturated imines catalyzed by a palladacycle has been developed, thus providing the access to a series of chiral tertiary enaminophosphines in high yields. A putative catalytic cycle has also been proposed.