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Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones:  Potent NK1 Antagonists

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posted on 13.11.2003, 00:00 by Gregory A. Reichard, Carmine Stengone, Sunil Paliwal, Ingrid Mergelsberg, Sapna Majmundar, Cheng Wang, Robert Tiberi, Andrew T. McPhail, John J. Piwinski, Neng-Yang Shih
A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a “self-reproduction of the center of chirality” strategy is described.

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