Asymmetric Palladium-Catalyzed C–H Functionalization Cascade for Synthesis of Chiral 3,4-Dihydroisoquinolones
dataset
posted on 2019-09-09, 19:13 authored by Manman Sun, Haijian Wu, Xiangyu Xia, Weida Chen, Zhiming Wang, Jianguo YangA palladium-catalyzed C–H
functionalization/intramolecular
asymmetric allylation cascade of <i>N</i>-sulfonyl benzamides
with 1,3-dienes has been developed. In the presence of a chiral pyridine–oxazoline
ligand, this protocol enables the synthesis of chiral 3,4-dihydroisoquinolones
in yields of up to 83% with enantioselectivities of up to 96%, using
environmentally friendly air as the terminal oxidant.
