jo6b02227_si_002.cif (11.84 kB)
Assembly of Polysubstituted Maleimides via Palladium-Catalyzed Cyclization Reaction of Alkynes with Isocyanides
dataset
posted on 2016-11-16, 00:00 authored by Weigao Hu, Jia Zheng, Jianxiao Li, Bifu Liu, Wanqing Wu, Haiyang Liu, Huanfeng JiangAn efficient and convenient palladium-catalyzed
cyclization reaction
of alkynes with isocyanides is described herein. This protocol allows
the practical synthesis of many valuable polysubstituted maleimide
derivatives after hydrolysis with a broad scope of substrates and
mild reaction conditions. C–C, CO, and C–N bonds
were constructed in this transformation with isocyanide serving as
both C and N sources.