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Aryne Compatible Solvents are not Always Innocent

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posted on 03.08.2016, 16:18 by Sung-Eun Suh, David M. Chenoweth
Arynes are important and versatile intermediates in a variety of transformations. Commonly used solvents for aryne chemistry include acetonitrile and dichloromethane. Although rarely reported, the reactive nature of aryne intermediates makes them prone to side reactions, which sometimes involve solvent participation. Acetonitrile and dichloromethane are not always innocent solvents and can participate in aryne-based reactions. These results are presented in the context of ongoing mechanistic investigations of the triple aryne–tetrazine reaction.