ja0c04159_si_002.cif (2.52 MB)

Arylphosphonate-Directed Ortho C–H Borylation: Rapid Entry into Highly-Substituted Phosphoarenes

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posted on 02.07.2020, 21:29 by Feiyang Xu, Olivia M. Duke, Daniel Rojas, Hanka M. Eichelberger, Raphael S. Kim, Timothy B. Clark, Donald A. Watson
Phosphonate-directed ortho C–H borylation of aromatic phosphonates is reported. Using simple starting materials and commercially accessible catalysts, this method provides steady access to o-phosphonate arylboronic esters bearing pendant functionality and flexible substitution patterns. These products serve as flexible precursors for a variety of highly substituted phosphoarenes, and in situ downstream functionalization of the products is described.