posted on 2021-11-15, 21:14authored byYing Fu, Yu-Xia Zhang, Liang-Liang Guo
The Catellani reaction provides an
efficient synthetic approach
to polyfunctionalized arenes. However, the selective ortho-arylating reagents employed in these reactions have been strictly
limited to activated bromoarenes. As demonstrated in this work, aryl
diazonium salts bearing both electron-donating and electron-withdrawing
substituents, after in situ transformations with KI into the corresponding
iodoarenes, were efficient arylating reagents for Catellani type ortho-arylation approaches.