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Aryl Diazonium Salts: Powerful Arylating Agents for Catellani-Type ortho-Arylation

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posted on 2021-11-15, 21:14 authored by Ying Fu, Yu-Xia Zhang, Liang-Liang Guo
The Catellani reaction provides an efficient synthetic approach to polyfunctionalized arenes. However, the selective ortho-arylating reagents employed in these reactions have been strictly limited to activated bromoarenes. As demonstrated in this work, aryl diazonium salts bearing both electron-donating and electron-withdrawing substituents, after in situ transformations with KI into the corresponding iodoarenes, were efficient arylating reagents for Catellani type ortho-arylation approaches.

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