Arene–Ruthenium(II) Complexes Containing 11H‑Indeno[1,2‑b]quinoxalin-11-one
Derivatives and Tryptanthrin-6-oxime: Synthesis, Characterization,
Cytotoxicity, and Catalytic Transfer Hydrogenation of Aryl Ketones
posted on 2020-05-07, 11:34authored byVladislava
V. Matveevskaya, Dmitry I. Pavlov, Taisiya S. Sukhikh, Artem L. Gushchin, Alexander Yu. Ivanov, Tatiana B. Tennikova, Vladimir V. Sharoyko, Sergey V. Baykov, Enrico Benassi, Andrei S. Potapov
A series
of novel mono- and binuclear arene–ruthenium(II)
complexes [(p-cym)Ru(L)Cl] containing 11H-indeno[1,2-b]quinoxalin-11-one derivatives or tryptanthrin-6-oxime
were synthesized and characterized by X-ray crystallography, IR, NMR
spectroscopy, cyclic voltammetry, and elemental analysis. Theoretical
calculations invoking singlet state geometry optimization, solvation
effects, and noncovalent interactions were done using density functional
theory (DFT). DFT calculations were also applied to evaluate the electronic
properties, and time-dependent DFT was applied to clarify experimental
UV–vis results. Cytotoxicity for cancerous and noncancerous
human cell lines was evaluated with cell viability MTT assay. Complexes
demonstrated a moderate cytotoxic effect toward cancerous human cell
line PANC-1. The catalytic activity of the complexes was evaluated
in transfer hydrogenation of aryl ketones. All complexes exhibited
good catalytic activity and functional group tolerance.