Approach to Isoindolinones, Isoquinolinones, and THIQs via Lewis Acid-Catalyzed Domino Strecker-Lactamization/Alkylations
dataset
posted on 2016-02-04, 00:00 authored by Sivasankaran Dhanasekaran, Arun Suneja, Vishnumaya Bisai, Vinod K. SinghA one-pot, three-component synthesis
of widely substituted isoindolinones
and isoquinolinones, featuring a Lewis acid-catalyzed efficient Strecker
reaction and lactamization sequence, affording products in good to
high yields is reported. The method has also been extended to the
synthesis of tetrahydroisoquinolines (THIQs) in high yields.
