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Anti-inflammatory Labdane Diterpenoids from Lagopsis supina

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posted on 25.04.2014, 00:00 by Hui Li, Man-Man Li, Xiao-Qin Su, Jing Sun, Yu-Fan Gu, Ke-Wu Zeng, Qian Zhang, Yun-Fang Zhao, Daneel Ferreira, Jordan K. Zjawiony, Jun Li, Peng-Fei Tu
Ten new labdane diterpenoids, lagopsins A–H (13, 5, 710) and 15-epi-lagopsins C and D (4, 6), together with five known labdane diterpenoids (1115), were isolated from the whole plants of Lagopsis supina. The absolute configuration of lagopsin A (1) was determined by single-crystal X-ray crystallographic analysis. Compounds 7, 9, 13, and 15 exhibited moderate inhibition of nitric oxide production stimulated by lipopolysaccharide in BV-2 microglial cells with IC50 values in the range 14.9–34.9 μM.