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Antcamphorols A–K, Cytotoxic and ROS Scavenging Triterpenoids from Antrodia camphorata

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posted on 2019-12-31, 16:03 authored by Bin Li, Yi Kuang, Jun-Bin He, Rui Tang, Lu-Lu Xu, Chung-Hang Leung, Dik-Lung Ma, Xue Qiao, Min Ye
Antrodia camphorata is a rare and valuable medicinal mushroom. In this work, 11 new triterpenoids, namely, antcamphorols A–K (111), together with 10 known triterpenoids, 1221, were isolated from dish-cultured A. camphorata. Compound 1 is an unprecedented C31 lanostane-type triterpenoid featuring a methyl group at C-15 and a C-21–O–C-24 tetrahydropyran ring at C-17. Compounds 211 are ergostane-type triterpenoids, and they include two pairs of norergostanes 25. The structures of the new compounds were identified by NMR, 2D NMR, and HRESIMS data analyses. The absolute configurations of 1 and 6 were defined by X-ray diffraction data, and the absolute configuration at C-25 of 4 was determined by the modified Mosher’s method. Compounds 7, 9, 10, 16, and 19 showed significant ROS scavenging activities (63.9–70.5% at 20 μM) in high-glucose-induced HUVECs. Compounds 3 and 8 exhibited moderate cytotoxic activities against U251 (IC50, 9.2 μM) and MCF-7 (IC50, 8.1 μM) human cancer cell lines, respectively.