posted on 2016-08-22, 21:18authored byDaniel Janssen-Müller, Santanu Singha, Theresa Olyschläger, Constantin G. Daniliuc, Frank Glorius
The activation of
2-(bromomethyl)benzaldehydes using
N-heterocyclic carbenes represents a novel approach to the generation
of o-quinodimethane (o-QDM) intermediates.
Coupling with ketones such as phenylglyoxylates, isatins, or trifluoromethyl
ketones via [4 + 2] annulation gives access to functionalized 1-isochromanones.