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An unexpected Bromolactamization of Olefinic Amides Using a Three-Component Co-catalyst System

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posted on 15.01.2016, 00:00 by Yi An Cheng, Wesley Zongrong Yu, Ying-Yeung Yeung
Reaction between (N,N-dimethylamino)­pyridine and isocyanate unexpectedly produced a three-component mixture. By using this mixture as an unprecedented three-component catalyst system, a facile and selective bromolactamization of olefinic amides has been developed. The protocol confers enhanced selectivity of N- over O-cyclization, leading to the formation of a structurally diverse range of lactams including both small and medium ring sizes.