American Chemical Society
ol302964x_si_002.cif (15.62 kB)

An Organic Molecule Modulated Chemoselective Cyclization of Alkynyl Nitriles Tethered to 2‑Alkyl Substituted Chromones with Multireactive Sites

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posted on 2012-12-21, 00:00 authored by Liping Huang, Yang Liu, Fuchun Xie, Youhong Hu
A small organic molecule phenylacetonitrile promoted chemoselective cyclization of (chromen-3-yl)alkynylnitriles to generate a novel tetracyclic or tricyclic chromone scaffold has been discovered. Importantly, the phenylacetonitrile serves as an anion transfer reagent changing the normal reaction of the substrate.