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An Efficient Rh/O2 Catalytic System for Oxidative C–H Activation/Annulation: Evidence for Rh(I) to Rh(III) Oxidation by Molecular Oxygen

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posted on 19.06.2013, 00:00 by Guoying Zhang, Lei Yang, Yanyu Wang, Yinjun Xie, Hanmin Huang
A novel and efficient Rh/O2 catalytic system has been developed and shown to catalyze highly efficient oxidative C–H activation/annulation reactions, producing a broad range of isoquinolinium salts with high turnover numbers (up to 740). Mechanistic studies provided strong evidence of facile oxidation of Rh­(I) to Rh­(III) by molecular oxygen facilitated by acid.