jo702130a_si_003.cif (12.79 kB)
An Efficient Method for the Synthesis of Nitropiperidones
dataset
posted on 2008-02-01, 00:00 authored by José Luis García Ruano, Teresa de Haro, Rajinder Singh, M. Belén CidA three step efficient strategy for the synthesis of substituted
5-nitropiperidones in high de, employing Michael addition
of N-p-tolylsulfinyl β-nitroamines to α,β-unsaturated esters,
hydrolysis of the sulfinyl group, and cyclization of the
resulting free amines, has been developed. A very simple
experimental procedure involving mild conditions and only
one chromatographic purification are the main features of
the process.