posted on 2014-09-05, 00:00authored byYi-Biao Wu, Yu Tang, Guo-Ying Luo, Yang Chen, Richard P. Hsung
A concise
and stereoselective synthesis of the trioxadispiroketal
motif that embodies the DEF-ring of the marine macrolide (+)-spirastrellolide
A is described. The synthetic approach features a sequence of cyclic
acetal tethered ring-closing metathesis and Suárez oxidative
cyclization, thereby constituting a viable strategy for constructing
the Northern Half.