American Chemical Society
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An Approach toward Constructing the Trioxadispiroketal Core in the DEF-Ring of (+)-Spirastrellolide A

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posted on 2014-09-05, 00:00 authored by Yi-Biao Wu, Yu Tang, Guo-Ying Luo, Yang Chen, Richard P. Hsung
A concise and stereoselective synthesis of the trioxadispiroketal motif that embodies the DEF-ring of the marine macrolide (+)-spirastrellolide A is described. The synthetic approach features a sequence of cyclic acetal tethered ring-closing metathesis and Suárez oxidative cyclization, thereby constituting a viable strategy for constructing the Northern Half.