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An Approach to the Core of Lactonamycin

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posted on 26.04.2017, 19:12 by Philip J. Parsons, Daniel R. Jones, Lee J. Walsh, Lewis A. T. Allen, Ada Onwubiko, Lewis Preece, Johnathan Board, Andrew J. P. White
A cascade reaction has been developed for the synthesis of lactonamycin. In this paper, we demonstrate that a transition-metal-free thermal ene–diyne cyclization can be used for the construction of the entire core of the antibiotic lactonamycin and anticancer agent lactonamycin Z.