co7b00033_si_005.cif (21.37 kB)
Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction
dataset
posted on 2017-02-27, 00:00 authored by Pravin Patil, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik, Alexander DömlingAmmonia in the tetrazole Ugi variation
together with α-amino
acid methyl ester-derived isocyanides provides tetrazolopiperidinones
in good to high yields in one pot. The scope and limitations of this
reaction were investigated by performing >70 reactions. The scaffold
is useful to fill high-throughput screening decks and in structure-based
drug design.