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Addition of Trifluoroborates to Oxetanyl N,O‑Acetals: Entry into Spiro and Fused Saturated Heterocycles

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posted on 02.07.2015, 00:00 authored by Patrick B. Brady, Erick M. Carreira
N,O-Acetals derived from 3-oxetanone and 1,2-amino alcohols undergo addition reactions with alkynyl-, allyl-, allenyl-, and vinylpotassium trifluoroborates. The resulting products undergo cyclization by orthogonal activation of the oxetane and the alkyne to give a diverse set of spiro and fused heterocycles.

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