ol5b01607_si_003.cif (896.58 kB)
Download file

Addition of Trifluoroborates to Oxetanyl N,O‑Acetals: Entry into Spiro and Fused Saturated Heterocycles

Download (896.58 kB)
posted on 2015-07-02, 00:00 authored by Patrick B. Brady, Erick M. Carreira
N,O-Acetals derived from 3-oxetanone and 1,2-amino alcohols undergo addition reactions with alkynyl-, allyl-, allenyl-, and vinylpotassium trifluoroborates. The resulting products undergo cyclization by orthogonal activation of the oxetane and the alkyne to give a diverse set of spiro and fused heterocycles.