ol7b02899_si_002.cif (424.51 kB)
Access to Alkyl-Substituted Lactone via Photoredox-Catalyzed Alkylation/Lactonization of Unsaturated Carboxylic Acids
dataset
posted on 2017-10-16, 21:13 authored by Wanxing Sha, Shengyang Ni, Jianlin Han, Yi PanAn efficient photoredox-catalyzed
alkylation/lactonization reaction
of unsaturated carboxylic acids by using alkyl N-hydroxyphthalimide
esters as alkylation reagents has been developed. Varieties of redox-active
esters derived from aliphatic carboxylic acids were proved viable
in this method, affording alkyl substituted lactones in moderate to
good yields. This redox-neutral procedure features mild conditions
and operational simplicity, which provides a new strategy for the
synthesis of alkyl substituted lactones.