American Chemical Society
jo901578r_si_002.cif (14.88 kB)

Aberrarone: A Gorgonian-Derived Diterpene from Pseudopterogorgia elisabethae

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posted on 2009-10-02, 00:00 authored by Ileana I. Rodríguez, Abimael D. Rodríguez, Hong Zhao
A marine metabolite based on a previously undescribed carbon skeleton, aberrarone (1), is reported as a natural product from the Caribbean sea whip, Pseudopterogorgia elisabethae. The molecular structure of the crystalline metabolite was established by spectral analysis and subsequently confirmed by X-ray crystallographic analysis. Aberrarone shows in vitro antimalarial activity against a chloroquine-resistant strain of the protozoan parasite Plasmodium falciparum.