ol702192m_si_003.cif (56.29 kB)

A Water-Soluble, Small Molecular Fluorescent Sensor with Femtomolar Sensitivity for Zinc Ion

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posted on 22.11.2007, 00:00 by Huan-Huan Wang, Quan Gan, Xiao-Jun Wang, Lin Xue, Sheng-Hua Liu, Hua Jiang
A water-soluble fluorescent sensor, 1, based on the quinoline platform, demonstrates femtomolar sensitivity for zinc ion with a 14-fold enhanced quantum yield upon chelation to zinc ion and also exhibits high selectivity to zinc ion over other physiological relevant divalent metals in the presence of EDTA. X-ray crystal structure of zinc complex reveals that an acetic carboxylic group participates in coordination, which significantly enhances the affinity of 1 for zinc ion.