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A Two-Directional Synthesis of (+)-β-Isosparteine

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posted on 13.06.2017, 16:18 by Firas M. Al-Saffar, Richard C. D. Brown
A two-directional synthesis of (+)-β-isosparteine is described in five steps from glutaric acid, where the entire carbon and nitrogen backbone of the alkaloid, possessing the requisite relative and absolute stereochemistry at its four stereogenic centers, is assembled using a double imino-aldol reaction.

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