American Chemical Society
ol401816y_si_002.cif (38.21 kB)

A Novel Chiral Bisphosphine-Thiourea Ligand for Asymmetric Hydrogenation of β,β-Disubstituted Nitroalkenes

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posted on 2013-08-02, 00:00 authored by Qingyang Zhao, Shengkun Li, Kexuan Huang, Rui Wang, Xumu Zhang
A novel chiral bisphosphine-thiourea ligand was developed and applied in the highly enantioselective hydrogenation of β,β-disubstituted nitroalkenes (up to 99% yield and 99% ee). With low catalytic loading (0.25 mol %), 98% ee and 98% conversion were obtained. The thiourea group takes on an important role in this catalytic system.