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A New Strategy for Efficient Synthesis of Medium and Large Ring Lactones without High Dilution or Slow Addition

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posted on 27.03.2013 by Wanxiang Zhao, Zigang Li, Jianwei Sun
We have developed an efficient method for medium and large ring lactone synthesis by a conceptually different ring-expansion strategy. The design of an unprecedented ring conjunction mode of oxetene, combined with the appropriate choice of a Lewis acid promoter and an additive, constitutes the key components of the new process. Enabled by this new approach, the reaction does not require high dilution or slow addition.