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A New Method for the Stereoselective Synthesis of α- and β-Glycosylamines Using the Burgess Reagent

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posted on 26.05.2004, 00:00 by K. C. Nicolaou, Scott A. Snyder, Annie Z. Nalbandian, Deborah A. Longbottom
Although glycosylamines constitute an important group of carbohydrates from the standpoint of biology and medicine, methods for their synthesis typically lack substrate generality and/or result in variable stereoselectivity, especially in complex contexts. In this communication, we report an operationally simple method for the synthesis of both α- and β-glycosylamines using the Burgess reagent that overcomes many of these limitations in a bare minimum of synthetic steps.