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A Modular Synthesis of Salvileucalin B Structural Domains

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posted on 19.08.2011, 00:00 by Chih-Chung Tseng, Hanfeng Ding, Ang Li, Yucui Guan, David Y.-K. Chen
A modular strategy leading to the salvileucalin B core structure has been accomplished. The developed synthetic strategy featured a bioinspired intramolecular Diels–Alder reaction to construct domain “A”, REDOX chemistry to functionalize domain “B”, and a palladium-mediated cross-coupling to install domain “C”. This flexible approach should facilitate further chemical and biological investigations of this fascinating class of compounds.

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