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A Metallocene-Pyrrolidinopyridine Nucleophilic Catalyst for Asymmetric Synthesis

Name: A Metallocene-Pyrrolidinopyridine Nucleophilic Catalyst for Asymmetric Synthesis
Published: 2006-02-16T00:00:00+00:00
License: https://creativecommons.org/licenses/by-nc/4.0/
Keywords: aceylated, ee, Steglich rearrangement, loading, Catalyst, Nucleophilic, Asymmetric Synthesis, aminopyridine, catalyst, mol, azlactone, hexane, nucleophilic, chiral

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posted on 2006-02-16, 00:00 authored by Huy V. Nguyen, David C. D. Butler, Christopher J. Richards

A highly active chiral 4-aminopyridine nucleophilic catalyst, available in three steps from (S,S)-hexane-2,5-diol, was applied to the asymmetric Steglich rearrangement of O-aceylated azlactones (1 mol % loading, up to 76% ee).

A Metallocene-Pyrrolidinopyridine Nucleophilic Catalyst for Asymmetric Synthesis

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