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A Metallocene-Pyrrolidinopyridine Nucleophilic Catalyst for Asymmetric Synthesis

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posted on 2006-02-16, 00:00 authored by Huy V. Nguyen, David C. D. Butler, Christopher J. Richards
A highly active chiral 4-aminopyridine nucleophilic catalyst, available in three steps from (S,S)-hexane-2,5-diol, was applied to the asymmetric Steglich rearrangement of O-aceylated azlactones (1 mol % loading, up to 76% ee).