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A Flexible Enantioselective Total Synthesis of Diospongins A and B and Their Enantiomers Using Catalytic Hetero-Diels−Alder/Rh-Catalyzed 1,4-Addition and Asymmetric Transfer Hydrogenation Reactions as Key Steps

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posted on 06.11.2009, 00:00 by Gullapalli Kumaraswamy, Gajula Ramakrishna, Police Naresh, Bharatam Jagadeesh, Balasubramanian Sridhar
A unified enantioselective route to total synthesis of diospongins A and B and their enantiomers has been developed employing achiral starting materials. All three stereocenters were introduced by means of catalytic reactions.