A Facile Route to Polysubstituted N-Benzyl Pyroglutamates
datasetposted on 10.04.2003 by Pei-Pei Sun, Meng-Yang Chang, Michael Y. Chiang, Nein-Chen Chang
Datasets usually provide raw data for analysis. This raw data often comes in spreadsheet form, but can be any collection of data, on which analysis can be performed.
Base-induced coupling/cyclization reactions of α-sulfonylacetamide with various ethyl (Z)-2-bromo-2-propenoates have been carried out. The polysubstituted pyroglutamate carbon skeleton, with three contiguous asymmetric centers, was built up in one step. A ring-closure mechanism is proposed for the reactions.