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A Domino Michael/Dieckmann Process as an Entry to α-(Hydroxymethyl)glutamic Acid

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posted on 02.09.2011, 00:00 by Carlos Aydillo, Gonzalo Jiménez-Osés, Alberto Avenoza, Jesús H. Busto, Jesús M. Peregrina, María M. Zurbano
A domino process that involves a Michael-type addition followed by a Dieckmann reaction mediated by the participation of the cyclic carbamate group is the key step in the synthesis of both enantiomers of α-(hydroxymethyl)glutamic acid (HMG).