jo300063u_si_001.cif (18.99 kB)

A 1,4-Diphenyl-1,2,3-Triazole-Based β-Turn Mimic Constructed by Click Chemistry

Download (18.99 kB)
posted on 04.05.2012, 00:00 by Chun-Fang Wu, Xin Zhao, Wen-Xian Lan, Chunyang Cao, Jin-Tao Liu, Xi-Kui Jiang, Zhan-Ting Li
A series of 1,4-diphenyl-1,2,3-triazole-incorporated amide derivatives have been designed and prepared. X-ray crystallographic and (1D and 2D) 1H NMR studies reveal that these compounds fold into stable U-shaped conformations driven by three-center intramolecular C–H···O hydrogen-bonding formed between the triazole C-5 H atom and the two ether O atoms. Such folded structures make this 1,4-diphenyl-1,2,3-triazole skeleton a good candidate to be used as β-turn mimic. To prove this, the formation of a β-hairpin structure induced by this β-turn motif has been further demonstrated.