cg301798s_si_002.cif (15.2 kB)
4‑Aminosalicylic Acid Adducts
dataset
posted on 2013-04-03, 00:00 authored by Suryanarayan Cherukuvada, Geetha Bolla, Kanishka Sikligar, Ashwini Nangia4-Aminosalicylic
acid (p-aminosalicylic acid, PAS), an antituberculosis
drug, is a model active pharmaceutical ingredient to study salt and
cocrystal formation in a multiple hydrogen-bonding functionality molecule
with carboxylic acid, amine, and phenol groups. A cytosine salt CYT+–PAS–, salt cocrystal hydrate CYT+–PAS––CYT–H2O, and nicotinamide cocrystal hydrate PAS–NAM–H2O, are described in this article. Furthermore, X-ray crystal
structures of PAS sodium dihydrate, sulfate, and mesylate salts and
dehydration/rehydration behavior of the sodium salt by powder X-ray
diffraction are discussed.