posted on 2015-11-06, 00:00authored byZhenbo Yuan, Xinxin Fang, Xuanyi Li, Jie Wu, Hequan Yao, Aijun Lin
A formal 1,6-conjugated addition-mediated
[2+1] annulation to synthesize
spiro[2.5]octa-4,7-dien-6-one with p-quinone methides
and sulfur ylides has been described. This domino-type process was
highly diastereoselective and exhibited good functional group tolerance
and scalability without the use of metals and bases.