American Chemical Society
jo5b01793_si_003.cif (21.94 kB)

1,6-Conjugated Addition-Mediated [2+1] Annulation: Approach to Spiro[2.5]octa-4,7-dien-6-one

Download (21.94 kB)
posted on 2015-11-06, 00:00 authored by Zhenbo Yuan, Xinxin Fang, Xuanyi Li, Jie Wu, Hequan Yao, Aijun Lin
A formal 1,6-conjugated addition-mediated [2+1] annulation to synthesize spiro[2.5]­octa-4,7-dien-6-one with p-quinone methides and sulfur ylides has been described. This domino-type process was highly diastereoselective and exhibited good functional group tolerance and scalability without the use of metals and bases.