np9b00059_si_002.cif (887.72 kB)

17-nor-Cephalotane-Type Diterpenoids from Cephalotaxus fortunei

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posted on 11.06.2019, 19:13 by Zhan-Peng Ge, Hong-Chun Liu, Guo-Cai Wang, Qun-Fang Liu, Cheng-Hui Xu, Jian Ding, Yao-Yue Fan, Jian-Min Yue
Seventeen new 17-nor-cephalotane-type diterpenoids, fortalpinoids A–Q (117), were isolated from the seeds of Cephalotaxus fortunei var. alpine. Compound 12 represents the first 17-nor-cephalotane-type diterpenoid featuring an 8-oxabicyclo[3.2.1]­oct-2-ene moiety. The absolute configuration of fortunolide A (18) was determined for the first time, and the structure of cephinoid Q was revised to 14-epi-cephafortoid A (24) by X-ray crystallographic data analysis. Some of the compounds showed significant cytotoxicity against A549 and HL-60 cells, and the structure–activity relationship of this compound class is discussed.