American Chemical Society
ja6b06623_si_012.cif (19.21 kB)

11-Step Total Synthesis of (−)-Maoecrystal V

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Version 2 2016-07-28, 13:52
Version 1 2016-07-26, 00:14
posted on 2016-07-26, 00:00 authored by Artiom Cernijenko, Rune Risgaard, Phil S. Baran
An expedient, practical, and enantioselective route to the highly congested ent-kaurane diterpene maoecrystal V is presented. This route, which has been several years in the making, is loosely modeled after a key pinacol shift in the proposed biosynthesis. Only 11 steps, many of which are strategic in that they build key skeletal bonds and incorporate critical functionalities, are required to access (−)-maoecrystal V. Several unique and unexpected maneuvers are featured in this potentially scalable pathway. Reevaluation of the biological activity calls into question the initial exuberance surrounding this natural product.