ol9b02899_si_001.pdf (8.43 MB)
i‑Pr2NMgCl·LiCl Enables the Synthesis of Ketones by Direct Addition of Grignard Reagents to Carboxylate Anions
journal contribution
posted on 2019-09-12, 18:36 authored by Kilian Colas, A. Catarina V.
D. dos Santos, Abraham MendozaThe
direct preparation of ketones from carboxylate anions is greatly
limited by the required use of organolithium reagents or activated
acyl sources that need to be independently prepared. Herein, a specific
magnesium amide additive is used to activate and control the addition
of more tolerant Grignard reagents to carboxylate anions. This strategy
enables the modular synthesis of ketones from CO2 and the
preparation of isotopically labeled pharmaceutical building blocks
in a single operation.