ao6b00163_si_001.pdf (58.3 MB)
O‑Aryl-Glycoside Ice Recrystallization Inhibitors as Novel Cryoprotectants: A Structure–Function Study
journal contribution
posted on 2016-10-24, 17:36 authored by Chantelle
J. Capicciotti, Ross S. Mancini, Tracey R. Turner, Toshie Koyama, Matthew G. Alteen, Malay Doshi, Takaaki Inada, Jason P. Acker, Robert N. BenLow-molecular-weight ice recrystallization
inhibitors (IRIs) are
ideal cryoprotectants that control the growth of ice and mitigate
cell damage during freezing. Herein, we describe a detailed study
correlating the ice recrystallization inhibition activity and the
cryopreservation ability with the structure of O-aryl-glycosides.
Many effective IRIs are efficient cryoadditives for the freezing of
red blood cells (RBCs). One effective cryoadditive did not inhibit
ice recrystallization but instead inhibited ice nucleation, demonstrating
the significance of inhibiting both processes and illustrating the
importance of this emerging class of cryoprotectants.