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Neisseria gonorrhoeae Becomes Susceptible to Polymyxin B and Colistin in the Presence of PBT2
journal contribution
posted on 2019-11-11, 19:05 authored by Freda E.-C. Jen, Arun V. Everest-Dass, Ibrahim M. El-Deeb, Sanjesh Singh, Thomas Haselhorst, Mark J. Walker, Mark von Itzstein, Michael P. JenningsNeisseria
gonorrhoeae (N. gonorrhoeae) causes
the sexually transmitted disease gonorrhea, which has a global incidence
of 106 million cases per year. No vaccine is available to prevent
the disease, and the emergence of multidrug resistant (MDR) strains
makes N. gonorrhoeae an immediate public health
threat. Here, we show that an ionophore, PBT2, can reverse the intrinsic
resistance of N. gonorrhoeae to polymyxin B
and colistin. These antibiotics administered in combination with PBT2
may be an effective path to treat MDR gonococcal infections.