jo3020775_si_001.pdf (1.47 MB)
[bmim][Br] as a Solvent and Activator for the Ga-Mediated Barbier Allylation: Direct Formation of an N‑Heterocyclic Carbene from Ga Metal
journal contribution
posted on 2012-12-21, 00:00 authored by Dibakar Goswami, Angshuman Chattopadhyay, Anubha Sharma, Subrata ChattopadhyayThe room-temperature ionic liquid (RTIL) [bmim][Br] has
been found
to be an excellent green and inexpensive medium for the Ga-mediated
allylation of aromatic and aliphatic aldehydes and ketones. The RTIL
activated the metal via formation of a Ga–N–heterocyclic carbene complex that assisted in the completion
of the reaction at ambient temperature with only 0.5 equiv of Ga and
1.2 equiv of allyl bromide with respect to the carbonyl substrates.
The present protocol required a much shorter time than those reported
in the literature using other metals and solvents and proceeded with
good yields and excellent selectivity.