am507817b_si_001.pdf (1.73 MB)
β‑Cyclodextrin Functionalized Magnetic Mesoporous Silica Colloid for Cholesterol Separation
journal contribution
posted on 2015-01-21, 00:00 authored by Arjyabaran Sinha, SK Basiruddin, Atanu Chakraborty, Nikhil R. JanaAlthough
cholesterol plays significant biochemical function in
the human body, excess of it leads to various disorders, and thus,
its control/separation is important in medical science and food industries.
However, efficient and selective separation of cholesterol is challenging
because cholesterol often exists in microheterogeneous or insoluble
forms in remote organ and exists with other chemicals/biochemicals.
Here, we have described a colloidal magnetic mesoporous silica (MMS)-based
approach for efficient separation of cholesterol in different forms.
MMS is functionalized with β-cyclodextrin for selective binding
with cholesterol via host–guest interaction. The colloidal
form of MMS offers effective interaction with cholesterol of any form,
and magnetic property of MMS offers easier separation of bound cholesterol.
Functionalized MMS is efficient in separating cholesterol crystals,
water-insoluble cholesterol, and the microheterogeneous form of cholesterol
from milk or a cellular environment. Developed material can be used
to remove cholesterol from a complex bioenvironment and extended for
large-scale cholesterol separation from food.