β‑C(sp3)–H Arylation of α‑Hydroxy Acid Derivatives Utilizing Amino Acid as a Directing Group
journal contributionposted on 18.12.2015 by Tetsuya Toba, Yi Hu, Anh T. Tran, Jin-Quan Yu
Any type of content formally published in an academic journal, usually following a peer-review process.
The Pd(II)-catalyzed arylation of unactivated β-C(sp3)–H bonds in α-hydroxy aliphatic acid with a variety of aryl iodides was developed utilizing an amino acid auxiliary as a directing group. This protocol provides access to biologically active β-arylated-α-hydroxy acid derivatives.